Defective fat storage
نویسندگان
چکیده
منابع مشابه
Defective fat storage
Like baby chicks, stem cells need a nest—a niche within the body where they reside and self-renew. Oguro et al. (page < A r t R e f v o l = " 2 0 3 " I s s = " 1 0 " > 2247< / A r t R e f >) find that, for blood stem cells, this nest is built by the same gene silencer that also helps them self-renew. This silencer is Bmi1, which turns off two cell cycle inhibitor genes, Ink4a and Arf, to promot...
متن کاملCell biology of fat storage
The worldwide epidemic of obesity and type 2 diabetes has greatly increased interest in the biology and physiology of adipose tissues. Adipose (fat) cells are specialized for the storage of energy in the form of triglycerides, but research in the last few decades has shown that fat cells also play a critical role in sensing and responding to changes in systemic energy balance. White fat cells s...
متن کاملHuman obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities.
An impaired ability to store fatty acids (FA) in subcutaneous adipose tissue (SAT) may be implicated in the pathogenesis of obesity-related diseases via overexposure of lean tissues and production of free radicals from FA oxidation (FAO). We studied regional FA metabolism in skeletal muscle and adipose tissue in humans and investigated the long-term effects of the FAO inhibitor trimetazidine on...
متن کاملExercise Training Reduces Intrathoracic Fat Regardless of Defective Glucose Tolerance
PURPOSE Epicardial (EAT) and pericardial (PAT) fat masses and myocardial triglyceride content (MTC) are enlarged in obesity and insulin resistance. We studied whether the high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) similarly decrease ectopic fat in and around the heart and whether the decrease is similar in healthy subjects and subjects with defecti...
متن کاملDefective thyroglobulin storage in LDL receptor-associated protein-deficient mice.
The molecular chaperone receptor-associated protein (RAP) is required for biosynthesis of megalin, an endocytic receptor for follicular thyroglobulin (Tg), the thyroid hormone precursor. RAP also binds to Tg itself, suggesting that it may affect Tg trafficking in various manners. To elucidate RAP function, we have studied the thyroid phenotype in RAP-knockout (RAP-KO) mice and found a reduction...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2006
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20310iti4